The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

Two teams heading in opposite directions match up on a cold Buffalo night. Here's what to know about Sunday night's game.

Buffalo had no problem beating San Francisco in the wintery conditions to win a fifth consecutive division title in Week 13.

The Bills return from their bye and will look to keep pace with the Kansas City Chiefs at the top of the AFC. Josh Allen has ...

Micah Roberts, on a 25-6 run on San Francisco 49ers picks, has revealed his Sunday Night Football expert picks for San ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

The Bills indeed stick with their ground game to answer the 49ers and score a touchdown at the end of the first quarter to ...

Buffalo has looked much more comfortable playing in the snowy conditions, scoring three TDs in the first half on Sunday.

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks ...

NFL Week 13 closes with Sunday Night Football as the San Francisco 49ers visit Highmark Stadium and the Buffalo Bills. Time ...

Fullback Kyle Juszczyk lost a fumble inside Buffalo’s 5-yard line when the 49ers were threatening to score. In totality, it ...

State and team officials brought all hands on deck to ensure that a massive dose of lake effect snow would not hinder Buffalo ...