The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

The Bills controlled the game on the ground as the snow played a significant role, with Buffalo finishing the game with 220 ...

If you didn't know the San Francisco 49ers were Super Bowl contenders last season, you might not believe it now. The 5–6 team ...

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...

San Francisco 49ers running back Christian McCaffrey's season might be over after he suffered a PCL injury on "Sunday Night ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

The San Francisco 49ers received some brutal news on Sunday evening. According to head coach Kyle Shanahan, running back ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

The Chiefs were the first team to clinch an NFL playoff berth, but the Bills can one-up them by sealing the AFC East with a ...

We're live with the Week 13 edition of "Sunday Night Football" as the Buffalo Bills play host to the San Francisco 49ers to ...

Buffalo Bills quarterback Josh Allen's third quarter touchdown was his second passing touchdown - and first receiving ...