Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

The NFC West is a bunched-up, crazy-tight race and it's probably going to stay that way during the final six weeks of the NFL ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two ...

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

With the Miami Dolphins taking a 30-17 loss to the Green Bay Packers on Thursday night, the Buffalo Bills can wrap up the AFC East for a fifth straight season o ...

After missing Week 12 with a shoulder injury, 49ers quarterback Brock Purdy is ready to get back on to the field. The ...

The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

According to Fox, the Cowboys and Giants Thanksgiving game racked up 38.5 million viewers. It's the fourth-most ever for a ...

NFL Nation reporters react to all the action, answering the biggest questions coming out of each game. Here's what we learned ...