Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

The NFC West is a bunched-up, crazy-tight race and it's probably going to stay that way during the final six weeks of the NFL ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

With the Miami Dolphins taking a 30-17 loss to the Green Bay Packers on Thursday night, the Buffalo Bills can wrap up the AFC East for a fifth straight season o ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

The Buffalo Bills have the chance to make team history on "Sunday Night Football" against the San Francisco 49ers.

Ravens quarterback Lamar Jackson has owned the NFC. But his 23-1 mastery will face a significant test from the Philadelphia ...

Cold weather remains the Miami Dolphins' kryptonite, as their three-game winning streak came to an end on Thanksgiving night ...

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December 1, ...

Green Bay Packers K Brandon McManus connects on a 24-yard field goal during Thursday's Week 13 game at Lambeau Field.