There's no two ways about it: the San Francisco 49ers are having a brutal season. Taking the field in Week 1 with sky-high ...

ORCHARD PARK, N.Y. (AP) — Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses ... This January, the NFL had to push ...

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

The San Francisco 49ers have been hit hard by injuries throughout the season. Another player added himself to the list, but he’s continuing to play. All-Pro linebacker Fred Warner revealed that he’s ...

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December ...

The San Francisco 49ers, despite careening toward the abyss of NFL mediocrity, still have a path to the postseason as they ...

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

Buffalo Bills head coach Sean McDermott has ruled out tight end Dalton Kincaid for Sunday night's game against the San ...

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the ...