The 49ers opened the practice window for safety Talanoa Hufanga, who has missed the last seven games with a wrist injury.

Kendrick Lamar and SZA announced the Grand National Tour, which will hit 19 stadiums across North America next spring and ...

Heartbreak has struck the 49ers family again with the news that the newborn son of left tackle Trent Williams died on Nov. 24 ...

The Buffalo Bills (9-2) will try to build on a six-game winning streak when they host the San Francisco 49ers (5-6) on Sunday ...

In honor of World Aids Day, San Franciscans came together at the National AIDS Memorial Grove in San Francisco on Saturday ...

Police have arrested a suspect in the murder of an Maxwell George Maltzman, 18, bringing to the forefront an unsolved San ...

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

Former San Francisco Giants president of baseball operations Farhan Zaidi may land a new gig in the near future.

Wells Fargo is set to sell its San Francisco headquarters, the Wall Street Journal reported on Tuesday, as the U.S. banking ...

San Francisco voters approved Proposition K transforming The Great Highway into a park. Now opponents of the plan have ...

The San Francisco Standard, that city’s lively and well-funded digital upstart, is experimenting with tiered membership.

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...