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The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 ...

The 49ers' third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at ...

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

The Bills are just having fun in the snow in Orchard Park, with one of the more unique touchdowns you'll ever see giving the ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

RB Christian McCaffrey, playing in just his fourth game since returning from an Achilles injury, left Sunday night's game at ...

Christian McCaffrey will not return to Sunday's matchup against the Bills. McCaffrey has been downgraded to out with the knee ...

San Francisco 49ers wide receiver Jauan Jennings rewards the 49ers' fourth-down call with a 26-yard catch and run.