The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

ET on Sunday, the Chicago Bears play at the San Francisco 49ers.In their last outing, the 49ers lost 35-10 to the Buffalo ...

The Buffalo Bills are used to hosting high-stakes games in the snow. So, it might not be a surprise that they easily defeated ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

The Miami Dolphins' Week 16 matchup against the San Francisco 49ers at Hard Rock Stadium is losing luster by the minute. What ...

The Buffalo Bills proved snow can't stop them, which we've seen time and again in Western New York (hey, why are they ...

San Francisco star running back Christian McCaffrey exited the 49ers Sunday Night Football game against the Bills with a knee ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

San Francisco 49ers quarterback Brock Purdy official game status revealed for Week 13 primetime matchup against the Buffalo ...

The Bills and 49ers play Sunday, Dec. 1 at 8:20 p.m. at Highmark Stadium in Orchard Park. The game will be broadcast on local ...

NFL Week 13 closes with Sunday Night Football as the San Francisco 49ers visit Highmark Stadium and the Buffalo Bills. Time ...