Following new injury reports, updated simulations reveal the best bet for 49ers vs. Bills on Sunday Night Football. Injury ...

Heavy snow is expected in Erie County, New York, this weekend, including when the AFC East-leading Bills host the 49ers for ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Brock Purdy speaks with reporters ahead of San Francisco's Week 13 matchup against the Buffalo Bills on Sunday night.49ers QB ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

A light dusting of snow began covering the Buffalo Bills' facility on Friday as the team completed its final practice of the ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

SANTA CLARA — It’s not like he was throwing at game speed, but the sight of Brock Purdy throwing the ball during warmups ...

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

Buffalo Bills rookie wide receiver Keon Coleman has been designated as questionable for his team's Week 13 matchup with the ...