RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury ...

Former Wisconsin running back Isaac Guerendo scored the second touchdown of his young NFL career in the San Francisco 49ers’ ...

Facing their seventh loss of the season, 49ers HC Kyle Shanahan gave an update on RB Christian McCaffrey who left the game ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The San Francisco 49ers sorely need a bounce-back win Sunday night, and quarterback Brock Purdy is returning at an ideal time ...

Quarterback Brock Purdy, inactive for the Week 12 loss to the Green Bay Packers last week, is expected to play head coach ...

Our NFL experts share their three favorite bets plus a special same-game parlay ahead of 49ers vs Bills on SNF on Sunday, ...

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Podcast; ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

Surgery could be on the horizon for Trevor Lawrence, but the Jacksonville Jaguars quarterback is expected to play on Sunday ...