One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be tough to do Sunday night in Buffalo - if they stand any chance of defending their crown because right now they’re in last place in the NFC West and sitting outside the NFC wild-card picture.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to tell members of the Buffalo Bills’ locker room that 2024 was supposed to be a rebuilding year.

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC champions sitting at 5-6.

San Francisco 49ers QB Brock Purdy (shoulder) is questionable to play in Sunday night's showdown against the Buffalo Bills, head coach Kyle Shanahan announced Friday.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth.

After its Week 11 party in Buffalo, "The NFL Today" crew is hitting the road again. This time, the NFL on CBS pregame show will broadcast live from Ford Field in anticipation of the Detroit Lions' Week 15 matchup against Josh Allen and the Buffalo Bills.